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Evaluation of Antiproliferative activity of Hydro-ethanolic extract of unripe fruit of carica papaya l. using various cell lines

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Plant based concoctions has become a significant element of various medical systems around the world. Majority of the plants studied have shown effective medicinal values. This study was undertaken to investigate the antiproliferative activity of Carica papaya L. The hydroethanolic extract of unripe fruit of C.papaya L (HEECP) was prepared. The qualitative and quantitative phytochemical analyses were performed. HT29 (colon cells) and HeLa (cervical cancer) were initially used for screening the antiproliferative activity of the crude extract by MTT assay. The extract showed pronounced activity against HeLa cell line suggesting interaction and inhibition of various components of cell cycle regulators. From the results obtained, it was concluded that Carica papaya L can be considered as a potent anticancer agent.

Keywords:Carica papaya L, antiproliferative, cell cycle regulators.


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